Name Shusuke TOMOSHIGE
Position Assistant Professor
Tel +81-22-217-6198
Mail stomoshi*tohoku.ac.jp (Please replace * with @)
Research Interest Medicinal Chemistry, Chemical Biology
Career Dr. Tomoshige completed his Ph.D. in pharmaceutical sciences at The University of Tokyo, Japan, in 2016 under the supervision of Prof. Yuichi Hashimoto. After his postdoctoral training for two years at University of Notre Dame, USA, under the guidance of Prof. Shahriar Mobashery, he joined Tokyo University of Science, Japan. Since September 2019, He has been appointed as an assistant professor at the Graduate School of Life Sciences, Tohoku University, Japan, working with Prof. Minoru Ishikawa.
Research map https://orcid.org/0000-0002-4948-5809
Research Projects

I have been working on the research on the degradation machinery of biopolymers (e.g. proteins and cell wall), especially ubiquitin-proteasome system (UPS). Recently, we have achieved the targeted protein knockdown of proteins involved in neurodegenerative disorders mediated by small molecules harnessing a ubiquitin ligase (E3), an enzyme conjugating ubiquitin to substrates, and currently are making an effort to expand the scope of the compounds. Also, I am challenging to develop the novel small molecules hijacking another E3.

Research Seeds